Empty Vegetable Capsule rau Clean Supplement Filling 

Npua zaub capsule ntau lawm tsis yog hais txog swapping gelatin rau cellulose thiab hu ua nws ua. Peb tau sau ntau dua 27 lab tshuaj ntsiav thoob plaws 14 hom tshuaj ntxiv - thiab kawm txoj hauv kev nyuaj uas "zaub zaub" tsis tau lees tias kev ua kom huv si, kev sib cais zoo ib yam, lossis kev ua raws cai. Dab tsi tseem ceeb yog * uas * npliag zaub capsule koj xaiv, nws coj li cas raws li kev tsim khoom tiag tiag, thiab seb koj lub capsule muab nws puas pom nws yog tus khub lossis teeb meem.

Yog vim li cas "Npua Zaub Capsule" yog ib tug Functional Specification - Tsis yog ib daim ntawv lo

Cov neeg yuav khoom feem ntau pib nrog kev thov kev noj haus: vegan, halal, tsis-GMO. Tab sis cov no yog kev lag luam lim - tsis yog engineering specs. Cov neeg tsav tsheb ua haujlwm tiag tiag zaum hauv peb txheej ntsuas tau: lub plhaub muaj pes tsawg leeg, qhov ntev ntev, thiab noo noo rhiab heev. Ntawm SUQIAN KELAIYA INTERNATIONAL TRADING CO., LTD, peb sim txhua ntau cov zaub tsis muaj tshuaj tiv thaiv USP General Tshooj <2040> TS EN ISO 8536-5 Kev sib xyaw ua ke ntawm qhov sib xws, thiab ASTM D5229 rau ya raws vapor kis tus nqi (MVTR). HPMC capsule ib txwm los ntawm peb lub chaw Jiangsu khiav ntawm 3.8-4.2% noo noo cov ntsiab lus - nruj txaus los tiv thaiv zoo li qub cling ntawm high-ceev fillers, ruaj khov txaus los tuav kev ncaj ncees thaum lub sij hawm 90-hnub stability kuaj ntawm 40 ° C / 75% RH.

Peb tau pom cov neeg siv khoom hloov pauv los ntawm HPMC cov tshuaj tuaj yeem mus rau peb cov qauv qib thiab txiav cov sijhawm ua tiav los ntawm 63%. Vim li cas? Vim tias peb cov plhaub muaj 0.018 hli phab ntsa thickness uniformity hla 100,000 units - qhov twg lwm tus txawv ± 0.006 hli. Qhov sib txawv ntawd ua rau jamming hauv dosator fillers khiav saum 120,000 cph. Nws kuj ua rau cov hmoov tsis sib xws, ua rau qhov hnyav sib txawv> ± 5% hauv cov koob tshuaj zaum kawg. Peb cov ntaub ntawv qhia tau hais tias zawm lub plhaub ovality rau ≤0.025 hli txo qhov hnyav ntawm qhov sib txawv ntawm 41%.

Tsis txhob xav tias txhua HPMC sib npaug. Qee tus neeg muag khoom siv hydroxypropyl methylcellulose nrog qis methoxy hloov (19-24%), uas softens saum 35 ° C. Lwm tus ntxiv cov neeg ua haujlwm gelling xws li carrageenan uas ncua kev sib cais dhau 45 feeb - ua tsis tiav USP <701> kev txiav txim siab. Peb tsuas yog siv hom E HPMC (methoxy 28–30%, hydroxypropyl 7–12%) tau txais los ntawm cov chaw muaj ntawv pov thawj ISO 22000. Txhua batch suav nrog CoA nrog viscosity (4–6 mPa·s @ 2% tov), ​​cov hmoov tshauv (<1.5%), thiab cov kuab tshuaj seem (tag nrho hauv qab ICH Q3C txwv).

Lub Filler-Capsule Interface: Qhov Kev Xav Tau Raws Li Jammed Hoppers

Qee tus yuav sib cav tias cov tshuaj ntsiav tshuaj ib leeg txiav txim siab ua tiav. Txawm li cas los xij, tsis muaj qhov khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob. Peb tau debugged filling tsis ua hauj lwm thoob teb dosator systems (MG2, IMA Zanasi), nruam band fillers (Capsugel FlexiFill), thiab semi-automatic benchtop units (CapPlus 300). Nyob rau hauv txhua rooj plaub, lub hauv paus ua rau taug qab mus rau mismatched mechanical cwj pwm - tsis raw khoom purity.

• Static charge buildup: Tsawg-MVTR plhaub (<5 g / m² / 24h) tsim triboelectric nqi thaum kev taw qhia. Peb ntxiv 0.12% cov khoom noj-qib silica rau peb tus qauv qib-txiav cov xwm txheej zoo li qub los ntawm 17/teev mus rau <1/teev ntawm 180,000 cph kab.
• Ejection quab yuam mismatch: Mos-shelled capsules buckle thaum ejection pins siv> 1.8 N quab yuam. Peb cov qib txhawb zog siv 0.8% rubulan co-blend, nce ejection tsis kam mus rau 2.6 N yam tsis muaj kev cuam tshuam lub sijhawm tawg.
• Lub tshuab nqus tsev foob tsis ua haujlwm: Capsules nrog ntxhib qhov chaw sab hauv xau lub tshuab nqus tsev thaum lub sij hawm dosator aspiration. Peb polish sab hauv phab ntsa rau Ra ≤0.4 µm - ua tiav 99.97% sau qhov tseeb ntawm cov hmoov nrog qhov ntom ntom <0.35 g / cm³.

Ib tus neeg siv cov kab hlwv keeb kwm tau tshaj tawm 12% capsule deformation thaum hloov mus rau blister hnab ris. Hloov mus rau peb qib kev sib txhuam qis-coated nrog 0.05% magnesium stearate-poob deformation rau 0.3%. Qhov txawv tsis yog chemistry. Nws yog nto zog tswj.

Tus nqi tsis yog nqi tsev xwb-Nws yog tawm los, ceev, thiab txee lub neej

Cov zaub tsis muaj tshuaj ntsiav nqi ntawm $ 0.018 txog $ 0.042 toj ib chav. Tab sis tus nqi-ib-dosed-unit qhia cov dab neeg tiag tiag. Xav txog qhov kev sib cais no rau 100 lab-lab-unit txhua xyoo khiav:

• Tus nqi qis qis ($ 0.019): 8.2% sau tsis lees paub tus nqi, 112,000 cph max ceev, 24-lub hlis txee lub neej
• Kelaiya tus qauv qib ($ 0.027): 1.4% tsis lees txais tus nqi, 148,000 cph max ceev, 36-hli txee lub neej
• Reinforced qib ($ 0.039): 0.6% tsis kam lees tus nqi, 165,000 cph max ceev, 42-hli txee lub neej

Kev ua lej yog unambiguous. Txawm hais tias ntawm $ 0.027, Kelaiya tus qauv qib muab 22% qis dua tus nqi tag nrho ntawm ib qho tshuaj ntsiav ua tiav - ua rau muaj kev ua haujlwm, poob qis, rov ua haujlwm, thiab kev ntsuas kev ruaj ntseg. Thiab vim tias peb cov tshuaj ntsiav dhau ICH Q5C kev kuaj pom kev zoo (tsis muaj UV-induced degradation nyob rau hauv vitamin B12 los yog curcumin formulations), cov neeg tau txais kev zam tsis raug nqi hloov pauv mus.

Peb tsis muag cov tshuaj ntsiav. Peb muag cov khoom kwv yees tau. Txhua qhov kev txiav txim nkoj nrog ntau qhov sib txawv ntawm qhov nkhaus, qhov hnyav faib histograms, thiab cov ntaub ntawv qhia txog kev sib raug zoo rau cov khoom siv sib xws - mannitol, microcrystalline cellulose, silicon dioxide. Tsis muaj kwv yees. Tsis muaj validation surprises.

Xaiv lub Npuas Zaub Capsule uas haum rau koj cov txheej txheem-tsis yog koj daim ntawv lo

Ib qho zaub qhwv khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob. Nws yuav tsum muaj sia nyob nrog kev ceev ceev, tiv thaiv cov rhiab heev, yaj hauv cov kua hauv plab, thiab ua tau raws li kev tswj hwm thoob ntiaj teb-tag nrho ua ntej thawj koob tawm hauv lub raj mis. General specs yuav tsis tau koj nyob ntawd. Tsis yog tus neeg muag khoom daim ntawv qhia cog lus tias "zoo tshaj plaws."

Dab tsi ua haujlwm yog kuaj raws li koj qhov xwm txheej. Tias yog vim li cas peb muab cov khoom siv coj mus kuaj dawb nrog tag nrho cov ntaub ntawv qhia kev-xws li cov yeeb yaj kiab qhia txog cov tshuaj ntsiav, cov ntaub ntawv sib cais ntawm pH 1.2/4.5/6.8, thiab cov ntawv sau-tus nqi ntawm lub sijhawm los ntawm peb cov kab tsav hauv Zhejiang. Koj yuav pom raws nraim li cas txhua qib coj tus cwj pwm ntawm koj cov cuab yeej - tsis yog peb li.

SUQIAN KELAIYA INTERNATIONAL TRADING CO., LTD ua haujlwm ob qhov chaw GMP-certified: ib qho hauv Jiangsu tsom rau high-precision HPMC plhaub extrusion, lwm qhov hauv Zhejiang integrating capsule filling thiab blister ntim validation. Ob leeg txhawb nqa FDA, Health Canada, thiab EU Annex 1 kev tshuaj xyuas. Tab sis daim ntawv pov thawj txhais tau tias tsis muaj dab tsi yog tias lub capsule jams koj muab tso rau ntawm 3 teev sawv ntxov hnub Monday.

Koj pawg tom ntej yuav tsum tsis txhob cuam tshuam rau kev cia siab. Nws yuav tsum khiav ntawm cov ntaub ntawv. Pib nrog cov zaub tsis muaj tshuaj ntsiav ua rau qhov koj txoj kev xav tau tiag tiag - tsis yog daim ntawv cog lus.